5-Maleimidovaleric acid

Names

[ Name ]:
5-Maleimidovaleric acid

[Synonym ]:
5-(2,5-dioxopyrrol-1-yl)pentanoic acid
5-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoic acid
1H-Pyrrole-1-pentanoic acid, 2,5-dihydro-2,5-dioxo-
5-Maleimidovaleric acid

Biological Activity

[Description]:

5-Maleimidovaleric acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
400.7±28.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₁NO₄

[ Molecular Weight ]:
197.188

[ Flash Point ]:
196.2±24.0 °C

[ Exact Mass ]:
197.068802

[ PSA ]:
74.68000

[ LogP ]:
0.56

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.544

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

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