Calcitonin, eel

Names

[ Name ]:
Calcitonin, eel

[Synonym ]:
MFCD00133858
EINECS 232-693-2
Calcitonin (eel)
HC 58
Eel Thyrocalcitonin
CYS-SER-ASN-LEU-SER-THR-CYS-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASP-VAL-GLY-ALA-GLY-THR-PRO-NH2(DISULFIDE BRIDGE:CYS1-CYS7)
Calcitonin, eel

Biological Activity

[Description]:

Calcitonin, eel is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Peptides

Research Areas >> Others

[In Vitro]

Calcitonin, eel effectively induces a concentration-dependent stimulation of phosphoinositide hydrolysis and stimulates prolactin release compared to salmon calcitonin in cultured anterior pituitary cells. However, Calcitonin, eel is inactive on the inhibition of prolactin release under thyrotropin releasing hormone (TRH) stimulated conditions[1].

[References]

[1]. Sortino MA, et al. Comparative effects of eel calcitonin, salmon calcitonin and [Asu1,7]eel calcitonin on hypophyseal and osteoblastic function. Gynecol Endocrinol. 1993 Jun;7(2):89-96.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄₆H₂₄₁N₄₃O₄₇S₂

[ Molecular Weight ]:
3414.87000

[ Exact Mass ]:
3412.72000

[ PSA ]:
1512.56000

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
3822009000

Customs

[ HS Code ]: 3822009000

Articles

The role of peptides and receptors of the calcitonin family in the regulation of bone metabolism.

Bone 43 , 813-818, (2008)

The 'calcitonin family' is a group of peptide hormones that share structural similarities with calcitonin, and includes calcitonin gene-related peptide (CGRP), amylin, adrenomedullin and adrenomedulli...

Signal transduction pathways of calcitonin/calcitonin receptor regulating cytoskeletal organization and bone-resorbing activity of osteoclasts.

Cell Mol. Biol. 52 , 19-23, (2006)

Calcitonin is a calcium-regulating peptide hormone that acts directly on osteoclasts and suppresses their function. In this review we will focus on the downstream signaling pathways of calcitonin rece...

Back to the future: revisiting parathyroid hormone and calcitonin control of bone remodeling.

Horm. Metab. Res. 42 , 299-306, (2010)

This review reflects on the past, present, and future of translational research on calcitropic hormones and bone metabolism. Calcitonin (CT) and parathormone (PTH) are complementary hormones involved ...

Related Compounds

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