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NSC 87877

Names

[ CAS No. ]:
56990-57-9

[ Name ]:
NSC 87877

[Synonym ]:
5-Quinolinesulfonic acid, 8-hydroxy-7-[(E)-2-(6-sulfo-2-naphthalenyl)diazenyl]-
8-Hydroxy-7-[(E)-(6-sulfo-2-naphthyl)diazenyl]-5-quinolinesulfonic acid
8-hydroxy-7-((6-sulfo-2-naphthyl)diazenyl)-5-quinolinesulfonic acid
8-Hydroxy-7-[(E)-(6-sulfo-2-naphthyl)diazenyl]quinoline-5-sulfonic acid
5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
8-Hydroxy-7-(6-sulfo-naphthalen-2-ylazo)-quinoline-5-sulfonic acid

Biological Activity

[Description]:

NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Others

[Target]

IC50: 0.318 μM (shp2), 0.355 μM (shp1)[1].


[References]

[1]. Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.

[2]. Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C19H13N3O7S2

[ Molecular Weight ]:
459.45

[ Exact Mass ]:
459.019501

[ PSA ]:
183.34000

[ LogP ]:
0.12

[ Index of Refraction ]:
1.758

Related Compounds