Butoxamine hydrochloride

Names

[ Name ]:
Butoxamine hydrochloride

[Synonym ]:
N-tert.-Butyl-pseudomethoxaminhydrochlorid
BUTOXAMINE HYDROCHLORIDE
Butoxamine hydrochloride (USAN)
BW 64-9
Butoxamine HCl
N-tert-Butylmethoxamine hydrochloride

Biological Activity

[Description]:

Butaxamine (Butoxamin) hydrochloride is a specific β2-adrenergic receptor blocker. Butaxamine hydrochloride inhibits the decreases in urine volume in ethanol-anesthetized, water-diuretic rats[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

Beta-2 adrenergic receptor

[In Vivo]

Butaxamine hydrochloride（25 μg/kg/min、50 μg/kg/min、100 μg/kg/min，15 分钟；静脉注射）提高了乙醇麻醉、水利尿大鼠的尿量水平[1]。

[References]

[1]. Shibouta Y, et al. Antidiuresis induced by beta1- and beta2-adrenergic agonists in ethanol-anesthetized rats. Eur J Pharmacol. 1978 Jan 15;47(2):149-57.

Chemical & Physical Properties

[ Boiling Point ]:
391ºC at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₆ClNO₃

[ Molecular Weight ]:
303.82500

[ Flash Point ]:
190.3ºC

[ Exact Mass ]:
303.16000

[ PSA ]:
50.72000

[ LogP ]:
3.70670

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Restoration of neutrophil immunocompetence after cardiopulmonary bypass by beta-adrenergic blockers.

Surgery 147(4) , 562-74, (2010)

To evaluate the possible protective effect of sympatholytic medications with respect to neutrophil function, we evaluated the influence of a nonselective beta-blocker medication on the interaction of ...

Does selective beta-1 blockade provide bone marrow protection after trauma/hemorrhagic shock?

Surgery 152(3) , 322-30, (2012)

Previously, nonselective beta-blockade (BB) with propranolol demonstrated protection of the bone marrow (BM) after trauma and hemorrhagic shock (HS). Because selective beta-1 blockers are used commonl...

Blocking of beta-2 adrenergic receptors hastens recovery from hypoglycemia-associated social withdrawal.

Psychoneuroendocrinology 33(10) , 1411-8, (2008)

Hypoglycemia is associated with a variety of adverse behaviors including fatigue, confusion and social withdrawal. While these clinical symptoms are well characterized, the mechanism of their cause is...

Related Compounds

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