THDOC

Names

[ CAS No. ]:
567-02-2

[ Name ]:
THDOC

[Synonym ]:
[3H]-Allotetrahydrodeoxycorticosterone
21-HYDROXYALLOPREGNANOLONE
TDOC
ALLOTETRADEOXYCORTICOSTERONE
ALLOTETRAHYDRO DOC
ALLOTETRAHYDRO SUBSTANCE 'Q'
ALLOTETRAHYDRODEOXYCORTICOSTERONE
ALLOTETRAHYDROCORTEXONE
ALLO TH DOC
5A-pregnane-3A,21-diol-20-one

Biological Activity

[Description]:

3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

Chemical & Physical Properties

[ Density]:
1.115g/cm3

[ Boiling Point ]:
470.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₁H₃₄O₃

[ Molecular Weight ]:
334.49300

[ Flash Point ]:
252.3ºC

[ Exact Mass ]:
334.25100

[ PSA ]:
57.53000

[ LogP ]:
3.56760

[ Index of Refraction ]:
1.54

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 976-977 , 6-18, (2015)

Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as ste...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...