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2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine

Names

[ CAS No. ]:
56632-83-8

[ Name ]:
2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine

[Synonym ]:
2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
4-Amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-cytosine
4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)pyrimidin-2(1H)-one
4-Amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-2(1H)-pyrimidinone
2'deoxy-2'-fluoroarabinocytidine
2'-Fluoro-2'-deoxy-arabinofuranosyl-cytidine

Biological Activity

[Description]:

2’-Deoxy-2’-fluoro-b-D-arabinocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
500.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H12FN3O4

[ Molecular Weight ]:
245.21

[ Flash Point ]:
256.2±32.9 °C

[ Exact Mass ]:
245.081177

[ PSA ]:
110.60000

[ LogP ]:
-1.26

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.697

Precursor & DownStream

Precursor

DownStream

Related Compounds