7Beta-Hydroxycholesterol

Names

[ CAS No. ]:
566-27-8

[ Name ]:
7Beta-Hydroxycholesterol

[Synonym ]:
5-Cholestene-3β,7β-diol
7β-hydroxycholesterol
7BETA-HYDROXYCHOLESTEROL
Cholest-5-ene-3,7-diol, (3β,7β,8ξ)-
7β-Hydroxy Cholesterol
(3β,7β,8ξ)-Cholest-5-ene-3,7-diol

Biological Activity

[Description]:

7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
515.3±38.0 °C at 760 mmHg

[ Melting Point ]:
165-167ºC

[ Molecular Formula ]:
C₂₇H₄₆O₂

[ Molecular Weight ]:
402.653

[ Flash Point ]:
214.7±21.4 °C

[ Exact Mass ]:
402.349792

[ PSA ]:
40.46000

[ LogP ]:
7.94

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.536

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S22-S26

[ RIDADR ]:
NONH for all modes of transport

Articles

Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers.

Br. J. Nutr. 114 , 368-75, (2015)

Toxic oxysterols in a hypercholesterolaemia-relevant proportion cause suicidal death of human erythrocytes or eryptosis. This process proceeds through early production of reactive oxygen species (ROS)...

Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.

Biochem. Pharmacol. 86(1) , 67-79, (2013)

There is some evidence that oxidized derivatives of cholesterol, 7-ketocholesterol (7KC) and 7β-hydroxycholesterol (7βOHC), are increased in the plasma of patients with neurodegenerative diseases asso...

[Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment].

Ugeskr. Laeg. 175(5) , 285-6, (2013)

Cerebrotendinous xanthomatosis (CTX) is a rare, but treatable lipid storage disorder caused by mutation in the CYP27A1 gene. The disorder results in deposition of cholestanol in various tissues. The c...