tirotundin

Names

[ Name ]:
tirotundin

[Synonym ]:
Propanoic acid, 2-methyl-, (3aS,4R,6S,9R,10S,11aR)-dodecahydro-9-hydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl ester
Titrotundine
TAGITININ-D
(1R,2S,4R,8S,9R,11S)-1-Hydroxy-2,11-dimethyl-7-methylene-6-oxo-5,14-dioxatricyclo[9.2.1.0]tetradec-9-yl 2-methylpropanoate

Biological Activity

[Description]:

Tirotundin (Tagitinin D) is a potent anti-inflammatory agent. Tirotundin inhibits the activation of NF-Kβ[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Tirotundin (compound 3) (5, 10, 20, 50 µM; 1 h；随后用 TNF-α 刺激一小时) 在浓度为 50 µM 时完全抑制 NF-Kβ 的激活[1]。

[References]

[1]. Rüngeler P, et al. Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets. Planta Med. 1998 Oct;64(7):588-93.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
493.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₈O₆

[ Molecular Weight ]:
352.42

[ Flash Point ]:
171.1±22.2 °C

[ Exact Mass ]:
352.188599

[ PSA ]:
82.06000

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.528

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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