dimethindene

Names

[ CAS No. ]:
5636-83-9

[ Name ]:
dimethindene

[Synonym ]:
Triten
Dimethpyrindene
Dimetindeno
N,N-dimethyl-3-[1-(2-pyridyl)ethyl]inden-2-ethylamine
Dimetindene
dimethyl-{2-[3-(1-pyridin-2-yl-ethyl)-inden-2-yl]-ethyl}-amine
Pecofenil
dimethindene
Dimetindenum
Foristal
Fenistil
Forhistal

Biological Activity

[Description]:

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH). Dimethindene can block K+ currents[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

Human Endogenous Metabolite


[In Vitro]

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM[2].

[In Vivo]

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure[1]. Animal Model: C57BL/6 mice with skin WH[1] Dosage: 0.25 mg Administration: intraperitoneal injection; once Result: Delayed skin wound closure as compared to vehicle treated mice.

Chemical & Physical Properties

[ Density]:
1.065 g/cm3

[ Boiling Point ]:
416.3ºC at 760 mmHg

[ Melting Point ]:
50 - 53 °C

[ Molecular Formula ]:
C20H24N2

[ Molecular Weight ]:
292.41800

[ Flash Point ]:
205.6ºC

[ Exact Mass ]:
292.19400

[ PSA ]:
16.13000

[ LogP ]:
4.14670

[ Index of Refraction ]:
1.587

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT0800000
CHEMICAL NAME :
Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-
CAS REGISTRY NUMBER :
5636-83-9
BEILSTEIN REFERENCE NO. :
0489974
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H24-N2
MOLECULAR WEIGHT :
292.46
WISWESSER LINE NOTATION :
L56 BHJ C2N1&1 DY1&- BT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
618 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
27 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
888 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,95,1973

Precursor & DownStream

Precursor

DownStream

Related Compounds