Mabuterol

Names

[ Name ]:
Mabuterol

[Synonym ]:
PB 868Cl
1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-butylamino)ethanol
1-[4-azanyl-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol
Ambuterol
Benzenemethanol,4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-(9CI)

Biological Activity

[Description]:

Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

Beta-2 adrenergic receptor

[References]

[1]. Yamamoto I, et al. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76.

[2]. Yaru Gu, et al. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion. Interactions, 2019, 307: 63-72.

Chemical & Physical Properties

[ Density]:
1.278g/cm3

[ Boiling Point ]:
375.9ºC at 760mmHg

[ Melting Point ]:
85-87ºC

[ Molecular Formula ]:
C₁₃H₁₈ClF₃N₂O

[ Molecular Weight ]:
310.74

[ Flash Point ]:
181.1ºC

[ Exact Mass ]:
310.10600

[ PSA ]:
58.28000

[ LogP ]:
4.33460

[ Index of Refraction ]:
1.516

[ Storage condition ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

[ HS Code ]:
2922199090

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%