56341-08-3

56341-08-3 structure

Name: Mabuterol
Chemical Name: mabuterol
CAS Number: 56341-08-3
Molecular Formula: C₁₃H₁₈ClF₃N₂O
Molecular Weight: 310.74
Catalog: API Respiratory medication Asthma
Create Date: 2018-07-11 00:17:37
Modify Date: 2024-01-02 11:35:52
Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].

Name	mabuterol
Synonyms	PB 868Cl 1-(4-Amino-3-chloro-5-(trifluoromethyl)phenyl)-2-(tert-butylamino)ethanol 1-[4-azanyl-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol Ambuterol Benzenemethanol,4-amino-3-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-5-(trifluoromethyl)-(9CI)

Description	Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	Beta-2 adrenergic receptor
References	[1]. Yamamoto I, et al. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. [2]. Yaru Gu, et al. Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion. Interactions, 2019, 307: 63-72.

Density	1.278g/cm3
Boiling Point	375.9ºC at 760mmHg
Melting Point	85-87ºC
Molecular Formula	C₁₃H₁₈ClF₃N₂O
Molecular Weight	310.74
Flash Point	181.1ºC
Exact Mass	310.10600
PSA	58.28000
LogP	4.33460
Index of Refraction	1.516
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere

HS Code	2922199090

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%