Ophiobolin B

Names

[ Name ]:
Ophiobolin B

[Synonym ]:
3,14-Dihydroxy-5-oxoophiobola-7,19-dien-25-al
Cochliobolin B

Biological Activity

[Description]:

Ophiobolin B, a sesterterpene metabolite of Helminthosporium oryzae, inhibits proton extrusion from maize coleoptiles. Ophiobolin B inhibits fusicoccin (FC) promoted proton extrusion, potassium uptake and cell enlargement[1]. The MIC values with the antifungal effect of Ophiobolins B on different zygomycetes is 25–50 μg/mL[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Anti-infection >> Fungal

[Target]

Fungal[2]

[References]

[1]. Gianani L, et al. Effects of ophiobolin B on cell enlargement and H(+)/K (+) exchange in maize coleoptile tissues. Planta. 1979 Jan;146(3):271-4.

[2]. Krizsán K, et al. Effect of the sesterterpene-type metabolites, ophiobolins A and B, on zygomycetes fungi. FEMS Microbiol Lett. 2010 Dec;313(2):135-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₈O₄

[ Molecular Weight ]:
402.56700

[ Exact Mass ]:
402.27700

[ PSA ]:
74.60000

[ LogP ]:
4.39160

Related Compounds

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