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Friedelin

Names

[ CAS No. ]:
559-74-0

[ Name ]:
Friedelin

[Synonym ]:
D:A-Friedooleanan-3-one
Einecs 209-205-1
(4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-Octamethylicosahydropicen-3(2H)-one
3-oxofriedelane
(4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-Octamethylicosahydro-3(2H)-picenone
3-friedelanone
3(2H)-Picenone, eicosahydro-4,4a,6b,8a,11,11,12b,14a-octamethyl-, (4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-
Friedeline
FRIEDELAN-3-ONE
Friedelin
friedelane-3-one

Biological Activity

[Description]:

Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79  μM and 6.16  μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54  μM and 18.02 μM, respectively[1].

[Related Catalog]:

Research Areas >> Others

[Target]

IC50: 10.79 μM (CYP3A4), 22.54 μM (CYP2E1); Ki: 6.16 μM(CYP3A4), 18.02 μM(CYP2E1)[1]


[References]

[1]. Wei J, et al. In vitro inhibitory effects of Friedelin on human liver cytochrome P450 enzymes. Pharm Biol. 2018 Dec;56(1):363-367.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
477.2±13.0 °C at 760 mmHg

[ Melting Point ]:
262-265ºC(lit.)

[ Molecular Formula ]:
C30H50O

[ Molecular Weight ]:
426.717

[ Flash Point ]:
233.9±12.1 °C

[ Exact Mass ]:
426.386169

[ PSA ]:
17.07000

[ LogP ]:
10.87

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.503

[ Storage condition ]:
2-8℃

MSDS

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Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds