Butibufen

Butibufen is a non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Butibufen (0.1 μM-0.1 M; 60 min) affects cell viability and cell attachment with a high dose[2]. Butibufen (1 μM; 48 h) causes a 100% cell death after 48 h exposure[2]. Butibufen (2 μM-1 mM; 6 h) affects synthesis of albumin in hepatocytes[2]. Butibufen (0.2-0.4 mM; 6 h) impaires gluconeogenesis from lactate and significantly inhibited ureogenesis[2]. Cell Viability Assay[2] Cell Line: Hepatocytes from Sprague-Dawley male rats Concentration: 0.1 μM-0.1 M Incubation Time: 60 min Result: Showed no cell viability effects under the dose of 200 μM, but dose- and time-dependently affected cell viability with higher concentrations.

Butibufen (50 and 250 mg/kg; p.o. 8 and 3 h before sacrifice) affects acid phosphatase activity[3]. Animal Model: Sprague-Dawley rats[3] Dosage: 50 and 250 mg/kg Administration: Oral gavage; 50 and 250 mg/kg; 8 and 3 h before sacrifice Result: Reduced acid phosphatase activity but showed no effect on the stabilization of lysosomal membrane.

[1]. Aparicio L. Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. Arch Int Pharmacodyn Ther. 1977 May;227(1):130-41.

[2]. Castell JV, et al. A study of the relative hepatotoxicity in vitro of the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen and butibufen. Xenobiotica. 1988 Jun;18(6):737-45.

[3]. Alamo C, et al. Influence of butibufen on enzyme activity and lysosomal stabilization ex vivo: a comparative study with hydrocortisone and acetylsalicylic acid. Methods Find Exp Clin Pharmacol.

MOLECULAR FORMULA :

C14-H20-O2

MOLECULAR WEIGHT :

220.34

WISWESSER LINE NOTATION :

QVY2&R D1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 227,130,1977

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

810 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,77,1978