DL-Serine hydroxamate

Names

[ Name ]:
DL-Serine hydroxamate

[Synonym ]:
dl-serine hydroxamate
serinehydroxamic acid
2-amino-3-hydroxy-propionohydroxamic acid
DL-Serine hydroxaMate seryl-tRNA synthetase inhibitor
D,L-serinehydroxamic acid

Biological Activity

[Description]:

DL-Serine hydroxamate is a serine derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃H₈N₂O₃

[ Molecular Weight ]:
120.10700

[ Exact Mass ]:
120.05300

[ PSA ]:
99.07000

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Selective inhibition of divergent seryl-tRNA synthetases by serine analogues.

FEBS Lett. 579(20) , 4344-8, (2005)

Seryl-tRNA synthetases (SerRSs) fall into two distinct evolutionary groups of enzymes, bacterial and methanogenic. These two types of SerRSs display only minimal sequence similarity, primarily within ...

Genome conformation capture reveals that the Escherichia coli chromosome is organized by replication and transcription.

Nucleic Acids Res. 41(12) , 6058-71, (2013)

To fit within the confines of the cell, bacterial chromosomes are highly condensed into a structure called the nucleoid. Despite the high degree of compaction in the nucleoid, the genome remains acces...

Serine hydroxamate and the transcriptome of high cell density recombinant Escherichia coli MG1655.

Appl. Biochem. Biotechnol. 157(2) , 124-39, (2009)

For more than 30 years, serine hydroxamate has been used to chemically stimulate a stringent response in Escherichia coli and other bacteria. These studies have elucidated numerous characteristics of ...

Related Compounds

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