Litorin

Names

[ Name ]:
Litorin

[Synonym ]:
5-Oxo-L-Pro-L-Gln-L-Trp-L-Ala-L-Val-Gly-L-His-L-Phe-L-Met-NH2
Efonidipine hydrochloride monoethanolate
M.W. 1084.47 C51H68N14O11S
pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
2-De-L-Val-3-de-L-Pro-ranatensin
Pituitary adenylate cyclase activating fragment 21-38
pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2,Pituitary adenylate cyclase activating fragment 21-38
GLP-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2
PYR-GLN-TRP-ALA-VAL-GLY-HIS-PHE-MET-NH2

Biological Activity

[Description]:

Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in vivo[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Bombesin Receptor

[In Vitro]

99mTc-Litorin is developed for non-invasive imaging of tumors with overexpressed gastrin-releasing peptide receptors (GRP-R)[1]. [D-Phe1,Leu8,9]Litorin inhibits binding of 125I-[Tyr4] BN to murine Swiss 3T3 cells with a Ki of 5.1 nM[2]. Litorin stimulates 3H-Thymidine incorporation in murine Swiss 3T3 cells with an EC50 of 2.3 nM[2].

[In Vivo]

Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in in vivo experiments[2].

[References]

[1]. Kam Leung. ^99mTc-pGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2. Molecular Imaging and Contrast Agent Database (MICAD). 2007 Oct 1.

[2]. J M Siegfried, et al. Effects of bombesin and gastrin-releasing peptide on human bronchial epithelial cells from a series of donors: individual variation and modulation by bombesin analogs. Anat Rec. 1993 May;236(1):241-7.

Chemical & Physical Properties

[ Density]:
1.34 g/cm3

[ Boiling Point ]:
1693.3ºC at 760 mmHg

[ Molecular Formula ]:
C₅₁H₆₈N₁₄O₁₁S

[ Molecular Weight ]:
1085.24

[ Flash Point ]:
977.9ºC

[ Exact Mass ]:
1084.49000

[ PSA ]:
417.85000

[ LogP ]:
2.74370

[ Index of Refraction ]:
1.615

Related Compounds

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