Propargyl-PEG1-acid

Names

[ Name ]:
Propargyl-PEG1-acid

[Synonym ]:
Propargyl-PEG1-acid

Biological Activity

[Description]:

Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1].

[References]

[1]. Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Boiling Point ]:
265.8ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₈O₃

[ Molecular Weight ]:
128.12600

[ Flash Point ]:
113.9ºC

[ Exact Mass ]:
128.04700

[ PSA ]:
46.53000

[ LogP ]:
0.11090

[ Index of Refraction ]:
1.463

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Related Compounds

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