Agrimol B

Names

[ Name ]:
Agrimol B

[Synonym ]:
1-Butanone, 1-[3,5-bis[[2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl]methyl]-2,4,6-trihydroxyphenyl]-2-methyl-, (2S)-
(2S)-1-[3,5-Bis(3-butyryl-2,6-dihydroxy-4-methoxy-5-methylbenzyl)-2,4,6-trihydroxyphenyl]-2-methyl-1-butanone
2-deacetyl wilformine
1-Butanone, 1-(3,5-bis((2,6-dihydroxy-4-methoxy-3-methyl-5-(1-oxobutyl)phenyl)methyl)-2,4,6-trihydroxyphenyl)-2-methyl-, (S)-

Biological Activity

[Description]:

Agrimol B is a polyphenol derived from Agrimonia pilosa Ledeb, suppresses adipogenesis via inducing SIRT1 translocation and expression, and reducing PPARγ expression[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Metabolic Disease

[Target]

SIRT1

PPARγ

[References]

[1]. Agrimol B, et al. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
922.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₇H₄₆O₁₂

[ Molecular Weight ]:
682.754

[ Flash Point ]:
284.4±27.8 °C

[ Exact Mass ]:
682.298950

[ PSA ]:
211.28000

[ LogP ]:
10.45

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.612

[ Storage condition ]:
-20°C

Related Compounds

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