NAADP tetrasodium salt

Names

[ CAS No. ]:
5502-96-5

[ Name ]:
NAADP tetrasodium salt

[Synonym ]:
NAADP tetrasodium salt

Biological Activity

[Description]:

NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

NAADP tetrasodium (2.5-10 μM) 诱导细胞毒性 T 淋巴细胞中酸性细胞内储存的 Ca2+ 释放[2]。 NAADP tetrasodium (10 μM，30 分钟) 刺激细胞毒性 T 淋巴细胞中的溶细胞颗粒胞吐作用[2]。

[In Vivo]

NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3]. Animal Model: LPS/GalN induced liver injury mice model[3] Dosage: 3-30 mg/kg Administration: 0.181 mg/kg, i.v. Result: Promoted autophagosome formation in in hepatocytes. Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes.

[References]

[1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326.

[2]. Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22(24):2331-7.

[3]. Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31(7):3126-3137.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₇N₆O₁₈P₃

[ Molecular Weight ]:
744.39

[ Exact Mass ]:
743.07500

[ PSA ]:
397.05000

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Involvement of actin filament in the generation of Ca2+ mobilizing messengers in glucose-induced Ca2+ signaling in pancreatic β-cells.

Islets 4(2) , 145-51, (2012)

Glucose is a metabolic regulator of insulin secretion from pancreatic β-cells, which is regulated by intracellular Ca(2+) signaling. We and others previously demonstrated that glucose activates CD38/A...

The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.

Biochem. J. 453(1) , 147-51, (2013)

TPCs (two-pore channels) are NAADP (nicotinic acid-adenine dinucleotide phosphate)-sensitive Ca2+-permeable ion channels expressed on acidic organelles. In the present study we show that deletion of t...

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.

J. Biol. Chem. 288(22) , 16017-30, (2013)

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date. Here, we report a new role for NAADP in arrhythmogenic Ca(2+) release in cardi...

Related Compounds

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