(±)9-HpODE

Names

[ Name ]:
(±)9-HpODE

[Synonym ]:
10,12-Octadecadienoic acid, 9-hydroperoxy-, (10E,12Z)-
(10E,12Z)-9-Hydroperoxy-10,12-octadecadienoic acid

Biological Activity

[Description]:

(±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

(±)9-HpODE (1-25 μM; 0-30 min) induces oxidation of intracellular glutathione (GSH) and with no cytotoxicity in BEAS-2B cells[1]. (±)9-HpODE (25 μM; 0-20 min) induces GSH oxidation is independent of secondary products or H2O2[1].

[References]

[1]. Corteselli EM, et, al. Long chain lipid hydroperoxides increase the glutathione redox potential through glutathione peroxidase 4. Biochim Biophys Acta Gen Subj. 2019 May;1863(5):950-959.

[2]. Sucharitha A, et, al. Antimicrobial properties of chilli lipoxygenase products. African Journal of Microbiology Research Vol. 4(9), pp. 748-752, 4 May 2010.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
447.7±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₃₂O₄

[ Molecular Weight ]:
312.444

[ Flash Point ]:
150.1±20.3 °C

[ Exact Mass ]:
312.230072

[ PSA ]:
66.76000

[ LogP ]:
6.14

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.491

Safety Information

[ HS Code ]:
2918990090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%