2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

Names

[ Name ]:
2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione

[Synonym ]:
4-nitrothalidomide
2-(2,6-dioxo-3-piperidinyl)-5-nitro-1H-isoindole-1,3(2H)-dione
2-(2,6-dioxo-piperidin-3-yl)-5-nitro-isoindole-1,3-dione
1H-Isoindole-1,3(2H)-dione,2-(2,6-dioxo-3-piperidinyl)-5-nitro
2-(4'-Nitro-phthalimido)-glutarimid
1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline
N-(2,6-dioxopiperidin-3-yl)-4-nitrophthalimide

Biological Activity

[Description]:

CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[References]

[1]. Heim C,et al. De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives. J Med Chem. 2019 Jul 25;62(14):6615-6629.

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₉N₃O₆

[ Molecular Weight ]:
303.23

[ Exact Mass ]:
303.04900

[ PSA ]:
132.86000

[ LogP ]:
0.73300

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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