8-Hydroxymethyl guanosine

Names

[ CAS No. ]:
54898-41-8

[ Name ]:
8-Hydroxymethyl guanosine

[Synonym ]:
8-hydroxymethylguanosine
8-hydroxymethyl-guanosine
8-(Hydroxymethyl)guanosin

Biological Activity

[Description]:

8-Hydroxymethyl guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H15N5O6

[ Molecular Weight ]:
313.27

[ Exact Mass ]:
313.10200

[ PSA ]:
179.74000

Related Compounds