Siastatin B microbial
Names
[ CAS No. ]:
54795-58-3
[ Name ]:
Siastatin B microbial
[Synonym ]:
(3S,4S,5R,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid
Chemical & Physical Properties
[ Density]:
1.48g/cm3
[ Boiling Point ]:
579.2ºC at 760 mmHg
[ Molecular Formula ]:
C8H14N2O5
[ Molecular Weight ]:
218.20700
[ Flash Point ]:
304.1ºC
[ Exact Mass ]:
218.09000
[ PSA ]:
118.89000
[ Index of Refraction ]:
1.581
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM6125400
- CHEMICAL NAME :
- 3-Piperidinecarboxylic acid, 6-(acetylamino)-4,5-dihydroxy-, (3S-(3-alpha,4-alpha,5-alpha,6- beta))-
- CAS REGISTRY NUMBER :
- 54795-58-3
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C8-H14-N2-O5
- MOLECULAR WEIGHT :
- 218.24
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,963,1974
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
TM6125400
[ HS Code ]:
2933399090
Synthetic Route
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Infect. Immun. 82(11) , 4620-30, (2014)
Previous studies showed that Clostridium perfringens type D animal disease strain CN3718 uses NanI sialidase for adhering to enterocyte-like Caco-2 cells. The current study analyzed whether NanI is si...
Syntheses and activities of N-substituted derivatives of siastatin B.J. Antibiot. 45(10) , 1662-8, (1992)
N-Substituted derivatives of siastatin B have been obtained by a chemical modification. Some derivatives showed potent inhibitory activities against Streptococcus sp. and Clostridium perfringens neura...
Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.J. Antibiot. 46(12) , 1883-9, (1993)
Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza...