4-Nitro-2-picoline-N-oxide
Names
[ CAS No. ]:
5470-66-6
[ Name ]:
4-Nitro-2-picoline-N-oxide
[Synonym ]:
2-methyl-4-nitro-pyridine-N-oxide
2-methyl-4-nitro-1-oxidopyridin-1-ium
MFCD00014625
4-Nitro-2-methylpyridine-N-oxide
4-Nitro-2-picoline-N-oxide
Pyridine, 2-methyl-4-nitro-, 1-oxide
2-Methyl-4-nitropyridine 1-oxide
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
404.0±25.0 °C at 760 mmHg
[ Melting Point ]:
155-159 °C(lit.)
[ Molecular Formula ]:
C6H6N2O3
[ Molecular Weight ]:
154.123
[ Flash Point ]:
198.1±23.2 °C
[ Exact Mass ]:
154.037842
[ PSA ]:
71.28000
[ LogP ]:
-0.09
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.585
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UT5710000
- CHEMICAL NAME :
- Pyridine, 2-methyl-4-nitro-, 1-oxide
- CAS REGISTRY NUMBER :
- 5470-66-6
- BEILSTEIN REFERENCE NO. :
- 0135501
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C6-H6-N2-O3
- MOLECULAR WEIGHT :
- 154.14
- WISWESSER LINE NOTATION :
- T6NJ AO B1 DNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1800 mg/kg/15W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - mouse Fibroblast
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,521,1975
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335-H351
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R20/21/22;R36/37/38;R40
[ Safety Phrases ]:
S22-S26-S36
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ RTECS ]:
UT5710000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2933399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Acta Crystallogr. Sect. E Struct. Rep. Online 70(Pt 4) , o426-7, (2014)
An improved crystal structure of the title compound, C6H6N2O3, is reported. The structure, previously solved [Li et al. (1987 ▶). Jiegou Huaxue (Chin. J. Struct. Chem.), 6, 20-24] in the ortho-rhom-bi...
Mononuclear copper(II) nitrato complexes with methyl-substituted 4-nitropyridine N-oxide. Physicochemical and cytotoxic characteristics.J. Inorg. Biochem. 104(2) , 153-60, (2010)
Three new complexes, products of the interaction of Cu(NO(3))(2) and methyl-substituted 4-nitropyridine N-oxides were synthesized and characterized by elemental analysis, magnetic, spectroscopic (IR, ...
Amination of alkyl substituted halogenopyridines with potassium amide in liquid ammonia. Van der Does L and Den Hertog HJ.Rec. Trav. Chim. 91(12) , 1403-1413, (1972)