U-0521

Names

[ Name ]:
U-0521

[Synonym ]:
U-0521
3',4'-Dihydroxyisobutyrophenone
3,4-Dihydroxyisobutyrophenon
3,4-Dihydroxyphenyl-isopropylketon
3',4'-Dihydroxy-2-methylpropiophenone

Biological Activity

[Description]:

U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson's disease[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

COMT[1]

[In Vitro]

U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC50 of 6 x10-6 M[1].

[In Vivo]

U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg[1]. Animal Model: Male Sprague-Dawley rats (180-250 g)[1] Dosage: 0-250 mg/kg Administration: i.p.; 10 min Result: Inhibited COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity was obtained at 90mg/kg and maximum inhibition of 90% was obtained at 250 mg/kg.

[References]

[1]. Reches A, et al. Effect of 3',4'-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. Biochem Pharmacol. 1982;31(21):3415-3418.

Chemical & Physical Properties

[ Density]:
1.191g/cm3

[ Boiling Point ]:
372.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₂O₃

[ Molecular Weight ]:
180.20000

[ Flash Point ]:
193.1ºC

[ Exact Mass ]:
180.07900

[ PSA ]:
57.53000

[ LogP ]:
1.93650

[ Index of Refraction ]:
1.565

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NQ5605000

CHEMICAL NAME :: Isobutyrophenone, 3',4'-dihydroxy-

CAS REGISTRY NUMBER :: 5466-89-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-O3

MOLECULAR WEIGHT :: 180.22

WISWESSER LINE NOTATION :: QR BQ DVY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,178,1964

Safety Information

[ HS Code ]:
2914501900

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914501900

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Related Compounds

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