3α-Dihydrocadambine

Names

[ Name ]:
3α-Dihydrocadambine

[Synonym ]:
3α-Dihydrocadambine
Methyl (4S,4aS,5S,14bS,15aS)-4-(β-D-glucopyranosyloxy)-5-hydroxy-4,4a,5,6,8,9,14,14b,15,15a-decahydropyrano[4'',3'':4',5']azepino[1',2':1,2]pyrido[3,4-b]indole-1-carboxylate
Pyrano[4'',3'':4',5']azepino[1',2':1,2]pyrido[3,4-b]indole-1-carboxylic acid, 4-(β-D-glucopyranosyloxy)-4,4a,5,6,8,9,14,14b,15,15a-decahydro-5-hydroxy-, methyl ester, (4S,4aS,5S,14bS,15aS)-
3a-Dihydrocadambine

Biological Activity

[Description]:

3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Takayama H, et al. Gluco-indole alkaloids from Nauclea cadamba in Thailand and transformation of 3 alpha-dihydrocadambine into the indolopyridine alkaloid, 16-carbomethoxynaufoline. Chem Pharm Bull (Tokyo). 2003;51(2):232-233.

[2]. K Aisaka, et al. Hypotensive action of 3 alpha-dihydrocadambine, an indole alkaloid glycoside of Uncaria hooks. Planta Med. 1985 Oct;51(5):424-7.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
802.9±65.0 °C at 760 mmHg

[ Melting Point ]:
182-187 °C

[ Molecular Formula ]:
C₂₇H₃₄N₂O₁₀

[ Molecular Weight ]:
546.57

[ Flash Point ]:
439.4±34.3 °C

[ Exact Mass ]:
546.221375

[ LogP ]:
-0.72

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.705

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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