Nek2/Hec1-IN-2

Names

[ Name ]:
Nek2/Hec1-IN-2

[Synonym ]:
MFCD03376422
2-Pyrazinecarboxamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-
N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-pyrazinecarboxamide

Biological Activity

[Description]:

Nek2/Hec1-IN-2 (Compound 14) is an inhibitor of Nek2/Hec1. Nek2/Hec1-IN-2 inhibits cancer cell proliferation with IC50 >25 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Nek2/Hec1[1]

[References]

[1]. Qiu XL, et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009 Mar 26;52(6):1757-67.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₁₆H₁₄N₄OS

[ Molecular Weight ]:
310.37

[ Exact Mass ]:
310.088837

[ LogP ]:
3.57

[ Index of Refraction ]:
1.668

Related Compounds

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