Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-13-methyl-, chloride (1:1)

Names

[ Name ]:
Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-13-methyl-, chloride (1:1)

[Synonym ]:
dehydrothalictricavine chloride
13-Methylberberinium chlorid
13-methylberberine chloride

Biological Activity

[Description]:

13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Chow YL, et al. 13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells. Sci Rep. 2016 Dec 5;6:38129.

[2]. Iwasa K, et al. In vitro cytotoxicity of the protoberberine-type alkaloids. J Nat Prod. 2001 Jul;64(7):896-8.

[3]. Lee DU, et al. Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages. Life Sci. 2003 Aug 1;73(11):1401-12.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₀ClNO₄

[ Molecular Weight ]:
385.84100

[ Exact Mass ]:
385.10800

[ PSA ]:
40.80000

[ LogP ]:
0.40870

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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