54260-72-9

54260-72-9 structure

Name: Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-13-methyl-, chloride (1:1)
Chemical Name: 2,3-methylenedioxy-10,11-dimethoxy-13-methylprotoberberine chloride
CAS Number: 54260-72-9
Molecular Formula: C₂₁H₂₀ClNO₄
Molecular Weight: 385.84100
Catalog: Research Areas Cancer
Create Date: 2017-04-18 18:33:02
Modify Date: 2025-09-20 18:22:15
13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS[1][2][3].

Name	2,3-methylenedioxy-10,11-dimethoxy-13-methylprotoberberine chloride
Synonyms	dehydrothalictricavine chloride 13-Methylberberinium chlorid 13-methylberberine chloride

Description	13-Methylberberine chloride (13-Methylberberinium chloride), a berberine analogue, has anti-adipogenic and antitumor activities. 13-Methylberberine chloride (13-Methylberberinium chloride) increases production of IL-12 and inhibits the expression of iNOS at posttranscriptional level in macrophages activated with LPS[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Chow YL, et al. 13-Methylberberine, a berberine analogue with stronger anti-adipogenic effects on mouse 3T3-L1 cells. Sci Rep. 2016 Dec 5;6:38129. [2]. Iwasa K, et al. In vitro cytotoxicity of the protoberberine-type alkaloids. J Nat Prod. 2001 Jul;64(7):896-8. [3]. Lee DU, et al. Effects of 13-alkyl-substituted berberine alkaloids on the expression of COX-II, TNF-alpha, iNOS, and IL-12 production in LPS-stimulated macrophages. Life Sci. 2003 Aug 1;73(11):1401-12.

50-00-0

483-15-8

~37%

54260-72-9

80665-65-2

54260-72-9

Literature: Hanaoka, Miyoji; Yoshida, Shuji; Mukai, Chisato Journal of the Chemical Society, Chemical Communications, 1985 , # 18 p. 1257 - 1258

100986-33-2

~80%

54260-72-9

Literature: Hanaoka; Yoshida; Mukai Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 12 p. 3264 - 3267

38699-81-9

54260-72-9

Literature: Naruto; Nishimura; Kaneko Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 6 p. 1271 - 1275

Precursor 4
50-00-0 483-15-8 80665-65-2 38699-81-9
DownStream 0