Reproterol

Names

[ Name ]:
Reproterol

[Synonym ]:
Reproterol [INN:BAN]
EINECS 258-956-1
7-{3-[2-(3,5-dihydroxy-phenyl)-2-hydroxy-ethylamino]-propyl}-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
7-{3-[2-(3,5-dihydroxyphenyl)-2-hydroxyethylamino]-propyl}-theophylline
Theophylline,7-(3-((2-(3,5-dihydroxyphenyl)-2-hydroxyethyl)amino)propyl)
Reproterolum [INN-Latin]
7-[3-[[2-(3,5-dihydroxyphenyl)-2-hydroxyethyl]amino]propyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
7-<3-<2-(3,5-dihydroxyphenyl)-2-hydroxyethylamino>propyl>-theophyllin
D 1959
Reproterol

Biological Activity

[Description]:

Reproterol is a dual acting β2-adrenoceptor agonist and PDE inhibitor. The theophylline constituent of Reproterol inhibits phosphodiesterase activity induced by adenylyl cyclase. Reproterol has the potential for asthma research[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Inflammation/Immunology

[Target]

β2 adrenoceptor

[References]

[1]. Uwe R Juergens, et al. Different mechanisms of action of beta2-adrenergic receptor agonists: a comparison of reproterol, fenoterol and salbutamol on monocyte cyclic-AMP and leukotriene B4 production in vitro. Eur J Med Res. 2004 Jul 30;9(7):365-70.

[2]. C G Georgakopoulos, et al. Excretion study of the beta2-agonist reproterol in human urine. J Chromatogr B Biomed Sci Appl. 1999 Apr 16;726(1-2):141-8.

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Boiling Point ]:
723.4ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₃N₅O₅

[ Molecular Weight ]:
389.41

[ Flash Point ]:
391.3ºC

[ Exact Mass ]:
389.17000

[ PSA ]:
134.54000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH5098950

CHEMICAL NAME :: Theophylline, 7-(3-((2-(3,5-dihydroxyphenyl)-2-hydroxyethyl)amino)p ropyl)-

CAS REGISTRY NUMBER :: 54063-54-6

BEILSTEIN REFERENCE NO. :: 0590567

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H23-N5-O5

MOLECULAR WEIGHT :: 389.46

WISWESSER LINE NOTATION :: T56 BN DN FNVNVJ B3N2QR CQ EQ& F1 H1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,14,1977

Related Compounds

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