2,7-dinitro-9H-fluorene
Names
[ CAS No. ]:
5405-53-8
[ Name ]:
2,7-dinitro-9H-fluorene
[Synonym ]:
9H-Fluorene, 2,7-dinitro-
EINECS 226-457-8
2,7-dinitro-9H-fluorene
MFCD00001121
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
451.5±38.0 °C at 760 mmHg
[ Melting Point ]:
330-334°C
[ Molecular Formula ]:
C13H8N2O4
[ Molecular Weight ]:
256.214
[ Flash Point ]:
229.9±19.6 °C
[ Exact Mass ]:
256.048401
[ PSA ]:
91.64000
[ LogP ]:
3.62
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.705
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LL7175000
- CHEMICAL NAME :
- Fluorene, 2,7-dinitro-
- CAS REGISTRY NUMBER :
- 5405-53-8
- BEILSTEIN REFERENCE NO. :
- 2057852
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C13-H8-N2-O4
- MOLECULAR WEIGHT :
- 256.23
- WISWESSER LINE NOTATION :
- L B656 HHJ ENW KNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2700 mg/kg/17W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - mouse Liver
- DOSE/DURATION :
- 2500 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,159,1987
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H351
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R40
[ Safety Phrases ]:
S7-S22-S36/37/39-S45
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
LL7175000
[ HS Code ]:
2904209090
Customs
[ HS Code ]: 2904209090
[ Summary ]:
2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Anal. Bioanal. Chem 397(1) , 233-41, (2010)
An electrochemical DNA biosensor based on the screen printed carbon paste electrode (SPCPE) with an immobilized layer of calf thymus double-stranded DNA has been used for in vitro investigation of the...
Preneoplastic lesions and DNA adduct formation of the airborne genotoxic agents 2-nitrofluorene and 2,7-dinitrofluorene.Carcinogenesis 14(12) , 2627-32, (1993)
The urinary mutagenicity (unconjugated forms) after administration of 2,7-dinitrofluorene (2,7-dNF) orally or i.p. was lower compared to 2-nitrofluorene (NF) administration. When partial hepatectomy (...
Reductions of nitro and 9-Oxo groups of environmental nitrofluorenes by the rat mammary gland in vitro.Chem. Res. Toxicol. 13(8) , 793-800, (2000)
Nitrofluorenes and C-9-oxidized nitrofluorenes are widespread environmental genotoxins which may be relevant for breast cancer on the basis of their carcinogenicities, particularly of 2, 7-dinitrofluo...