Letosteine

Names

[ Name ]:
Letosteine

[Synonym ]:
Viscotiol
Letosteine
Letosteinum
Letosteina

Biological Activity

[Description]:

Letosteine is an orally active, potent and safe expectorant. Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research[1][2][3].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vivo]

Letosteine (Sprague-Dawley rats, 20 mg/kg, IV or Orally, once) is rapidly excreted with mainly in urine[4]. Animal Model: Sprague-Dawley rats Dosage: 20 mg/kg Administration: IV or Orally, once Result: Rapidly was excreted with mainly in urine. More than 86% of the administered [14C]-radioactivity was recovered in urine within 72 h, 5-7% of the administered [14C]-radioactivity was recovered as 14CO2 in the expired air.

[References]

[1]. [1]Jia L. Letosteine. John Wiley & Sons, Ltd, 2014.

[2]. [2] Macquet V, et al. A new contribution to the treatment of chronic bronchopneumopathies: letosteine. Lille Med. 1979;24(9):735-738.

[3]. [3] Zhou Y, et al. Efficacy and safety of letosteine in the treatment of sputum thickening and expectoration difficulty in patients with respiratory diseases: a multicenter, randomized, double-masked, double dummy, positive drug parallel controlled trial. Pharmazie. 2014;69(11):842-849.

[4]. [4] Gachon F, et al. Disposition and metabolism of letosteine in rats. Drug Metab Dispos. 1988;16(6):853-857.

Chemical & Physical Properties

[ Density]:
1.284 g/cm3

[ Boiling Point ]:
470ºC at 760 mmHg

[ Melting Point ]:
142ºC

[ Molecular Formula ]:
C₁₀H₁₇NO₄S₂

[ Molecular Weight ]:
279.38

[ Flash Point ]:
238.1ºC

[ Exact Mass ]:
279.06000

[ PSA ]:
126.23000

[ LogP ]:
1.11730

[ Index of Refraction ]:
1.547

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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