4-(2H4)Pyridinecarboxylic acid

Names

[ CAS No. ]:
53907-55-4

[ Name ]:
4-(2H4)Pyridinecarboxylic acid

[Synonym ]:
(H)Pyridine-4-carboxylic acid
4-(H)Pyridinecarboxylic acid
4-Pyridine-d-carboxylic acid

Biological Activity

[Description]:

Isonicotinic acid-d4 is the deuterium labeled Isonicotinic acid[1]. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Seng KY, et al. Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers. Antimicrob Agents Chemother. 2015 Nov;59(11):6791-9.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
396.0±15.0 °C at 760 mmHg

[ Molecular Formula ]:
C6HD4NO2

[ Molecular Weight ]:
127.134

[ Flash Point ]:
193.3±20.4 °C

[ Exact Mass ]:
127.057137

[ PSA ]:
50.19000

[ LogP ]:
0.54

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.571

Related Compounds