Onitin

Names

[ Name ]:
Onitin

[Synonym ]:
4-Hydroxy-6-(2-hydroxyethyl)-2,2,5,7-tetramethyl-1-indanone
Onitin
1H-Inden-1-one, 2,3-dihydro-4-hydroxy-6-(2-hydroxyethyl)-2,2,5,7-tetramethyl-
4-hydroxy-6-(2-hydroxyethyl)-2,2,5,7-tetramethyl-2,3-dihydro-1H-inden-1-one

Biological Activity

[Description]:

Onitin is a natural product, that can be isolated from Onychium siliculosum. Onitin is also a non-competitive antagonist of histamine. Onitin shows activity in blocking the peristaltic reflex of the guinea-pig ileum, in inhibition of the responses of guinea-pig ileum to histamine and of inhibition of the responses of guinea-pig tracheal muscle to histamine[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Wu T S, et al. Flavanone and other constituents from Onychium siliculosum. Phytochemistry, 1981, 20(3):527–529.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
445.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₂₀O₃

[ Molecular Weight ]:
248.318

[ Flash Point ]:
237.3±25.2 °C

[ Exact Mass ]:
248.141251

[ PSA ]:
57.53000

[ LogP ]:
2.92

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.570

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Related Compounds

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