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Evernic Acid

Names

[ CAS No. ]:
537-09-7

[ Name ]:
Evernic Acid

[Synonym ]:
EINECS 208-658-2
Lecanoric acid methyl ether
Evernic acid,pruiss
Monomethylaether-p-diorsellinsaeure
2-hydroxy-4-methoxy-6-methylbenzoic acid 4'-carboxy-3'-hydroxy-5'-methylphenyl ester
Evernic acid
Monomethylaether-lecanorsaeure

Biological Activity

[Description]:

Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

Fungal Metabolite


[References]

[1]. Lee S, et al. Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson's Disease Model. Int J Mol Sci. 2021;22(4):2098. Published 2021 Feb 20.

Chemical & Physical Properties

[ Density]:
1.391g/cm3

[ Boiling Point ]:
531.8ºC at 760mmHg

[ Melting Point ]:
166-167ºC

[ Molecular Formula ]:
C17H16O7

[ Molecular Weight ]:
332.30500

[ Flash Point ]:
194.6ºC

[ Exact Mass ]:
332.09000

[ PSA ]:
113.29000

[ LogP ]:
2.64060

[ Index of Refraction ]:
1.576

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GP4195000
CHEMICAL NAME :
2,6-Cresotic acid, 4-methoxy-, 4-ester with 6-methyl-beta-resorcylate
CAS REGISTRY NUMBER :
537-09-7
BEILSTEIN REFERENCE NO. :
2227186
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H16-O7
MOLECULAR WEIGHT :
332.33
WISWESSER LINE NOTATION :
QR CQ E1 DVOVR BQ F1 DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01633

Safety Information

[ HS Code ]:
2918990090

Precursor & DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%


Related Compounds