Atilmotin

Names

[ Name ]:
Atilmotin

[Synonym ]:
8565
4WQQ18VL49
L-Lysinamide, N-[(2S)-1-oxo-3-phenyl-2-(trimethylammonio)propyl]-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosylglycyl-L-α-glutamyl-L-leucyl-L-glutaminyl-D-arginyl-L-leucyl-, inne r salt
N-[(2S)-3-Phenyl-2-(trimethylammonio)propanoyl]-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosylglycyl-5-oxidanidyl-5-oxidanylidene-L-norvalyl-L-leucyl-L-glutaminyl-D-arginyl-L-leucyl-L-lysinamide

Biological Activity

[Description]:

OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Motilin Receptor

[Target]

pKd: 8.94 (Motilin Receptor)[1]

[References]

[1]. Peeters T L. Motilin and the Discovery and Development of Motilinomimetics. Old Herborn University Seminar Monograph. INSTITUTE FOR MICROBIOLOGY AND BIOCHEMISTRY, 1997, 9: 77-87.

[2]. Korimilli A, Parkman HP. Effect of atilmotin, a motilin receptor agonist, on esophageal, lower esophageal sphincter, and gastric pressures. Dig Dis Sci. 2010 Feb;55(2):300-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₆H₁₃₅N₂₀O₁₉+

[ Molecular Weight ]:
1753.11

[ Exact Mass ]:
1751.013428

[ LogP ]:
-1.50

Related Compounds

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