533927-56-9

533927-56-9 structure

Name: Atilmotin
Chemical Name: 8565
CAS Number: 533927-56-9
Molecular Formula: C₈₆H₁₃₅N₂₀O₁₉+
Molecular Weight: 1753.11
Catalog: Signaling Pathways GPCR/G Protein Motilin Receptor
Create Date: 2021-09-12 15:32:23
Modify Date: 2024-04-05 17:46:22
OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents[1][2].

Name	8565
Synonyms	8565 4WQQ18VL49 L-Lysinamide, N-[(2S)-1-oxo-3-phenyl-2-(trimethylammonio)propyl]-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosylglycyl-L-α-glutamyl-L-leucyl-L-glutaminyl-D-arginyl-L-leucyl-, inne r salt N-[(2S)-3-Phenyl-2-(trimethylammonio)propanoyl]-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosylglycyl-5-oxidanidyl-5-oxidanylidene-L-norvalyl-L-leucyl-L-glutaminyl-D-arginyl-L-leucyl-L-lysinamide

Description	OHM 11638 (Atilmotin), an analogue of the (1-14) fragment of porcine motilin, is a motilin receptor agonist with a pKd of 8.94 for the motilin receptor. OHM 11638 affects esophageal, lower esophageal sphincter (LES), and gastric motility. OHM 11638 increases LES and gastric pressures, OHM 11638 can be used as prokinetic agents[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Motilin Receptor
Target	pKd: 8.94 (Motilin Receptor)[1]
References	[1]. Peeters T L. Motilin and the Discovery and Development of Motilinomimetics. Old Herborn University Seminar Monograph. INSTITUTE FOR MICROBIOLOGY AND BIOCHEMISTRY, 1997, 9: 77-87. [2]. Korimilli A, Parkman HP. Effect of atilmotin, a motilin receptor agonist, on esophageal, lower esophageal sphincter, and gastric pressures. Dig Dis Sci. 2010 Feb;55(2):300-6.