L-Pinaverium bromide

Names

[ Name ]:
L-Pinaverium bromide

[Synonym ]:
4-(6-Bromoveratryl)-4-[2-[2-(6,6-dimethyl-2-norpinyl)ethoxy]ethyl]morpholinium Bromide
LAT 1717
Dicetel
EINECS 258-450-0
Pinaverium bromide
UNII-7SCF54H12J
Morpholinium, 4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]-, bromide (1:1)
4-(2-Bromo-4,5-dimethoxybenzyl)-4-{2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl}morpholin-4-ium bromide
4-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]morpholinium Bromide

Biological Activity

[Description]:

Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Others

[Target]

Calcium channel[1].

[References]

[1]. Dai Y, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.

Chemical & Physical Properties

[ Melting Point ]:
159-164ºC

[ Molecular Formula ]:
C₂₆H₄₁Br₂NO₄

[ Molecular Weight ]:
591.416

[ Exact Mass ]:
589.140198

[ PSA ]:
36.92000

[ LogP ]:
2.25510

[ Storage condition ]:
-20°C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QF2810000

CHEMICAL NAME :: Morpholinium, 4-(2-bromo-4,5-dimethoxy)benzyl-4-(2-(2-(6,6-dimethyl -2-norpinyl)ethoxy) ethyl)-, bromide

CAS REGISTRY NUMBER :: 53251-94-8

LAST UPDATED :: 199109

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C26-H41-Br-N-O4.Br

MOLECULAR WEIGHT :: 591.50

WISWESSER LINE NOTATION :: L46 ATJ A1 A1 E2O2- AT6K DOTJ A1R BE DO1 EO1 &E &24/47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 504 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 40,133,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,182,1974

Precursor & DownStream

Precursor

DownStream

Related Compounds

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