acridine-3,6-diamine dihydrochloride

Names

[ CAS No. ]:
531-73-7

[ Name ]:
acridine-3,6-diamine dihydrochloride

[Synonym ]:
Proflavine dihydrochloride
2,8-Diaminoacridinium chloride hydrochloride
EINECS 208-515-4
Acridine-3,6-diamine dihydrochloride
ACRIDINE,3,6-DIAMINO-,DIHYDROCHLORIDE
3,6-Diaminoacridinium chloride hydrochloride
proflavin.2HCl
3,6-Diaminoacridine dihydrochloride
acridine-3,6-diamine,dihydrochloride

Biological Activity

[Description]:

Proflavine (3,6-Diaminoacridine) dihydrochloride, an acridine dye, is a DNA intercalating agent and Anti-microbial agent. Proflavine dihydrochloride behaves as a pore blocker for Kir3.2. Proflavine dihydrochloride is a potential lead compound for Kir3.2-associated neurological diseases[1][2][3].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

[2]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.

[3]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

Chemical & Physical Properties

[ Boiling Point ]:
506.9ºC at 760mmHg

[ Molecular Formula ]:
C₁₃H₁₃Cl₂N₃

[ Molecular Weight ]:
282.17

[ Flash Point ]:
292.9ºC

[ Exact Mass ]:
281.04900

[ PSA ]:
64.93000

[ LogP ]:
5.31880

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR8700000

CHEMICAL NAME :: Acridine, 3,6-diamino-, dihydrochloride

CAS REGISTRY NUMBER :: 531-73-7

LAST UPDATED :: 199409

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H11-N3.2Cl-H

MOLECULAR WEIGHT :: 282.19

WISWESSER LINE NOTATION :: T C666 BNJ EZ MZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 20 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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