scopolin

Names

[ CAS No. ]:
531-44-2

[ Name ]:
scopolin

[Synonym ]:
Scopolin
2H-1-Benzopyran-2-one, 7-(β-D-glucopyranosyloxy)-6-methoxy-
Scopoletin glucoside
7-(β-D-glucopyranosoyloxy)-6-methoxy-2H-1-benzopyran-2-one
2H-1-Benzopyran-2-one, 7- (β-D-glucopyranosyloxy)-6-methoxy-
5Mg
7-(b-D-Glucopyranosyloxy)-6-methoxy-2H-1-benzopyran-2-one
Scopoletin 7-O-Glucoside
6-Methoxy-2-oxo-2H-chromen-7-yl β-D-glucopyranoside
2'-β-D-glucosyl scopolin
Murrayin
Scopolin (8CI)
CPD-678
Scopoletin 7-glucoside
7β-D-Glucopyranosyloxy-6-methoxycoumarin
Scopoline
Scopoloside

Biological Activity

[Description]:

Scopolin is a coumarin isolated from Arabidopsis thaliana (Arabidopsis) roots[1]. Scopolin attenuated hepatic steatosis through activation of SIRT1-mediated signaling cascades[2].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Research Areas >> Metabolic Disease

[Target]

SIRT1

[References]

[1]. Siwinska J, et al. Identification of QTLs affecting scopolin and scopoletin biosynthesis in Arabidopsisthaliana. BMC Plant Biol. 2014 Oct 18;14:280.

[2]. Yoo A, et al. Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver. Sci Rep. 2017 May 22;7(1):2251.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
650.2±55.0 °C at 760 mmHg

[ Melting Point ]:
217ºC

[ Molecular Formula ]:
C₁₆H₁₈O₉

[ Molecular Weight ]:
354.309

[ Flash Point ]:
241.5±25.0 °C

[ Exact Mass ]:
354.095093

[ PSA ]:
138.82000

[ LogP ]:
-1.87

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.639

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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