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Cholic acid-13C

Names

[ CAS No. ]:
52886-36-9

[ Name ]:
Cholic acid-13C

[Synonym ]:
<24-13C>-Cholsaeure
<24-13C>-Chenodeoxycholsaeure
(3α,5β,7α,12β)-3,7,12-Trihydroxy(24-C)cholan-24-oic acid
Cholan-24-oic-24-C acid, 3,7,12-trihydroxy-, (3α,5β,7α,12β)-
Cholan-24-oic-24-C acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)-
(3α,5β,7α,12α)-3,7,12-Trihydroxy(24-C)cholan-24-oic acid

Biological Activity

[Description]:

Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684.

[3]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C24H40O5

[ Molecular Weight ]:
409.564

[ Exact Mass ]:
409.290924

[ PSA ]:
97.99000

[ LogP ]:
3.44870

[ Index of Refraction ]:
1.558

Related Compounds