Deoxycholic acid-13C

Names

[ Name ]:
Deoxycholic acid-13C

[Synonym ]:
Cholan-24-oic-24-C acid, 3,12-dihydroxy-, (3α,5β,12α)-
3a,12a-Dihydroxy-5|A-cholanic acid-24-13C
Cholan-24-oic-24-C acid, 3,12-dihydroxy-, (3α,5β,12β)-
7-Deoxycholic acid-24-13C
(3α,5β,12β)-3,12-Dihydroxy(24-C)cholan-24-oic acid
<24-13C>-Deoxycholsaeure
Deoxycholic acid-24-13C
Desoxycholic acid-24-13C
(3α,5β,12α)-3,12-Dihydroxy(24-C)cholan-24-oic acid
3a,12a-Dihydroxy-5ß-cholanic acid-24-13C,7-Deoxycholic acid-24-13C,Desoxycholic acid-24-13C

Biological Activity

[Description]:

Deoxycholic acid-13C (Cholanoic acid-13C) is the 13C-labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GPCR19

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Somm E, et al. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. JCI Insight. 2017 Apr 20;2(8). pii: 91809.

[3]. Wang X, et al. Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in micedependent on c-Myc expression. Cancer Med. 2017 Apr;6(4):788-797.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₄₀O₄

[ Molecular Weight ]:
393.565

[ Exact Mass ]:
393.296021

[ PSA ]:
77.76000

[ LogP ]:
4.47790

[ Index of Refraction ]:
1.543

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ RIDADR ]:
NONH for all modes of transport