aflatoxin Q1

Names

[ Name ]:
aflatoxin Q1

[Synonym ]:
Aflatoxin Q1
3-hydroxy-Aflatoxin B1

Biological Activity

[Description]:

Aflatoxin Q1 is a hydroxy metabolite of Aflatoxin B1 (AFB1), which is a mycotoxin produced by Aspergillus flavus (A. flavus). Aflatoxin Q1, as well as and aflatoxin B1 8,9-oxide, is the major oxidative products formed from aflatoxin B1 in human liver microsomes, at all substrate concentrations. the 3 alpha-hydroxylation of aflatoxin B1 to aflatoxin Q1 is a potentially significant detoxication pathway[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Raney KD, et al. Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. Chem Res Toxicol. 1992 Mar-Apr;5(2):202-10.

[2]. Yamada M, et al. Detoxification of Aflatoxin B1 Contaminated Maize Using Human CYP3A4. J Microbiol Biotechnol. 2020 Aug 28;30(8):1207-1213.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₂O₇

[ Molecular Weight ]:
328.27

[ Exact Mass ]:
328.05800

[ PSA ]:
95.20000

[ LogP ]:
1.76740

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
UN 3172