beta-Asarone

Names

[ Name ]:
beta-Asarone

[Synonym ]:
EINECS 226-096-6
Benzene, 1,2,4-trimethoxy-5-(1-propenyl)-
1,2,4-trimethoxy-5-propenyl-benzene
cis-Isoasarone
1,2,4-trimethoxy-5-prop-1-enylbenzene
Benzene, 1,2,4-trimethoxy-5-propenyl-, trans-
(Z)-1,2,4-Trimethoxy-5-(1-propenyl)benzene
beta-asarone
1,2,4-trimethoxy-5-propenylbenzene
Benzene, 1,2,4-trimethoxy-5- (1-propenyl)-
Benzene, 1,2,4-trimethoxy-5-[(1Z)-1-propen-1-yl]-
1,2,4-Triméthoxy-5-[(1Z)-1-propèn-1-yl]benzène
Benzene, 1,2,4-trimethoxy-5-propenyl-
(Z)-5-Propenyl-1,2,4-trimethoxybenzene
b-Asarone
MFCD00009281
Benzene, 1,2,4-trimethoxy-5-(1-propenyl)-, (Z)-
cis-Beta-Asarone
1,2,4-trimethoxy-5-[(1Z)-prop-1-en-1-yl]benzene
2,4,5-Trimethoxy-1-propenylbenzene
1,2,4-Trimethoxy-5-propenyl-benzol
2,4,5-trimethoxyphenylprop-1-ene
Benzene, 1,2,4-trimethoxy-5-propenyl-, (Z)-
cis-1-Propenyl-2,4,5-trimethoxybenzene
1,2,4-Trimethoxy-5-[(1Z)-1-propen-1-yl]benzene

Biological Activity

[Description]:

Beta-asarone is a major ingredient of Acorus tatarinowii Schott, penetrates blood brain barrier, with the properties ofimmunosuppression, central nervous system inhibition, sedation, and hypothermy. Beta-asarone protects against Parkinson’s disease[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Zhang QS, et al. Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression. Biomed Pharmacother. 2016 Oct;83:153-159.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
296.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₆O₃

[ Molecular Weight ]:
208.254

[ Flash Point ]:
107.7±23.8 °C

[ Exact Mass ]:
208.109940

[ PSA ]:
27.69000

[ LogP ]:
2.98

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.526

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC3000000

CHEMICAL NAME :: Benzene, 1,2,4-trimethoxy-5-propenyl-, (Z)-

CAS REGISTRY NUMBER :: 5273-86-9

BEILSTEIN REFERENCE NO. :: 1910605

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C12-H16-O3

MOLECULAR WEIGHT :: 208.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 500 umol/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 32,223,1994

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
23-24/25

[ WGK Germany ]:
3

[ RTECS ]:
DC3000000

[ HS Code ]:
2909309090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%