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Flucloxacillin

Names

[ CAS No. ]:
5250-39-5

[ Name ]:
Flucloxacillin

[Synonym ]:
Flucloxacillin
Floxapen
Culpen
(2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Flopen
(2S,5R,6R)-6-({[3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Abboflox
EINECS 226-051-0
Flucil
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
Flupen
Ladropen
MFCD00864886
Floxacillin
Staphcil
Staphylex
FK 900
Penplus
Stafoxil
BRL 2039

Biological Activity

[Description]:

Flucloxacillin is an active antibiotic against gram-positive and gram-negative bacteria[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vivo]

Flucloxacillin (200 mg/kg; i.p.; three times/day, for 21 days; male Wistar rats) has effective against the most common bacterial strains in periprosthetic infection[1]. Animal Model: Male Wistar rats[1] Dosage: 200 mg/kg Administration: Intraperitoneal injection; three times/day, for 21 days Result: Reducted germs in the biofilm and in the bone tissue.

[References]

[1]. Greimel F, et, al. Efficacy of antibiotic treatment of implant-associated Staphylococcus aureus infections with moxifloxacin, flucloxacillin, rifampin, and combination therapy: an animal study. Drug Des Devel Ther. 2017 Jun 14;11:1729-1736.

[2]. Comber KR, Merrikin DJ, Sutherland R. Antibacterial activity and synergy, in vitro and in vivo, of a combination of amoxycillin and flucloxacillin. Chemotherapy. 1979;25(1):30-9.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
677.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H17ClFN3O5S

[ Molecular Weight ]:
453.872

[ Flash Point ]:
363.4±31.5 °C

[ Exact Mass ]:
453.056152

[ PSA ]:
138.04000

[ LogP ]:
2.60

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.672

Related Compounds