Mebhydrolin

Names

[ CAS No. ]:
524-81-2

[ Name ]:
Mebhydrolin

[Synonym ]:
Mebhydrolin
5-Benzyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indol
Mebhydrolinum [INN-Latin]
Mebhydroline
5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol
9-benzyl-3-methyl-1,2,3,4-tetrahydro-3-carboline
3-methyl-9-benzyl-1,2,3,4-tetrahydrocarboline
Mebhydroline [INN-French]
Mebhidrolina [INN-Spanish]
EINECS 208-364-4

Biological Activity

[Description]:

Mebhydrolin is a specific histamine H1 receptor antagonist.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

[Target]

Histamine H1-receptor[1]

[In Vitro]

Mebhydrolin is a specific histamine H1-receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study[2].

[References]

[1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7.

[2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.12 g/cm3

[ Boiling Point ]:
856.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₀N₂

[ Molecular Weight ]:
276.37600

[ Flash Point ]:
471.6ºC

[ Exact Mass ]:
276.16300

[ PSA ]:
8.17000

[ LogP ]:
3.61540

[ Index of Refraction ]:
1.633

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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