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Malonyl CoA

Names

[ CAS No. ]:
524-14-1

[ Name ]:
Malonyl CoA

[Synonym ]:
2,6-Dioxo-cyclohexancarbaldehyd
2-formyl-1,3-cyclohexanedione
2,6-dioxo-cyclohexanecarbaldehyde
S-(HYDROGEN MALONYL)COENZYME A
3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoicacid
S-(HYDROGEN MALONYL)COENZYME A

Biological Activity

[Description]:

Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite


[In Vitro]

丙二酰辅酶A (20 μM，6分钟) 抑制 MCF-7 细胞 CPT1 活性 (降低 75%)[2]. 丙二酰辅酶A (0-3 μM) 抑制雌性大鼠肝线粒体中的 CPT1 活性[3].

[References]

[1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87.  

[2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23.  

[3]. Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H38N7O19P3S

[ Molecular Weight ]:
853.58000

[ Exact Mass ]:
853.11600

[ PSA ]:
455.66000

Precursor & DownStream

Precursor

DownStream

Related Compounds