Bilobetin

Names

[ CAS No. ]:
521-32-4

[ Name ]:
Bilobetin

[Synonym ]:
3''',8-Biflavone,4',5,5'',7,7''-pentahydroxy-4'''-methoxy
4'-monomethylamentoflavone
4'-methylamentoflavone
8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Bilobetin
4H-1-Benzopyran-4-one, 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
4'-O-methylamentoflavone

Biological Activity

[Description]:

Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Metabolic Disease

[Target]

PPARα

PKA

[References]

[1]. Kou XH, et al. Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet. Br J Pharmacol. 2012 Apr;165(8):2692-706.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
869.9±65.0 °C at 760 mmHg

[ Melting Point ]:
296-298ºC

[ Molecular Formula ]:
C₃₁H₂₀O₁₀

[ Molecular Weight ]:
552.484

[ Flash Point ]:
291.9±27.8 °C

[ Exact Mass ]:
552.105652

[ PSA ]:
170.80000

[ LogP ]:
4.20

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.750

Safety Information

[ Hazard Codes ]:
Xi