Dromostanolone propionate

Names

[ CAS No. ]:
521-12-0

[ Name ]:
Dromostanolone propionate

[Synonym ]:
Androstan-3-one, 2-methyl-17-(1-oxopropoxy)-, (2α,5α,17β)-
2a-Methyl-17b-(1-oxopropoxy)-5a-androstan-3-one
Masteril
Dromostanolone 17-propionate
MDHT
(2α,5α,17β)-2-Methyl-3-oxoandrostan-17-yl propionate
Dromostanolone propionate
Emdisterone
17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate
EINECS 208-303-1
5α-Androstan-3-one, 17β-hydroxy-2α-methyl-, propionate
Drostanolone propionate
Masterone
(2α,5α,17β)-2-methyl-3-oxoandrostan-17-yl propanoate
Permastril
Medrotestron propionate
2a-Methylandrostan-17b-ol-3-one Propionate
MFCD01669961
Dromostanolone proprionate
Drolban
Masterid
UNII-X20UZ57G4O
17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate

Biological Activity

[Description]:

Dromostanolone propionate (Drostanolone propionate) is a compound has antitumor activity against breast carcinoma[1]. Dromostanolone propionate inhibits the uptake of oestradiol-17ß by the tumour but has no apparent effect on the uptake by normal breast tissue [2]. Dromostanolone propionate implant pellet produces weight gains in animals and suppresses estrus in female animals[3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Takeuchi S, et al. Clinical experience with dromostanolone propionate (NSC-12198) in breast carcinoma. Saishin Igaku. 1967 May;22(5):1049-54.

[2]. N.Deshpande, et al. Accumulation of tritiated oestradiol by human breast tissue. Steroids, 1967 Sep;10(3), 219–232.

[3]. Brian H. Vickery . Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals. US3991750A.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
445.9±45.0 °C at 760 mmHg

[ Melting Point ]:
114-120ºC

[ Molecular Formula ]:
C₂₃H₃₆O₃

[ Molecular Weight ]:
360.530

[ Flash Point ]:
190.5±28.8 °C

[ Exact Mass ]:
360.266449

[ PSA ]:
43.37000

[ LogP ]:
5.67

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Storage condition ]:
Controlled Substance, -20?C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8067300

CHEMICAL NAME :: 5-alpha-Androstan-3-one, 17-beta-hydroxy-2-alpha-methyl-, propionate

CAS REGISTRY NUMBER :: 521-12-0

BEILSTEIN REFERENCE NO. :: 3161958

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H36-O3

MOLECULAR WEIGHT :: 360.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,534,1982

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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