Pectolinarigenin

Names

[ CAS No. ]:
520-12-7

[ Name ]:
Pectolinarigenin

[Synonym ]:
Flavone, 5,7-dihydroxy-4',6-dimethoxy-
4'-Methylcapillarisin
5,7-Dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
6-Hydroxypelargidenon-6,4'-dimethyl Ether
6-Methoxyacacetin
5,7-dihydroxy-6,4'-dimethoxyflavone
5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)chromen-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)-
pictolinarigenin
scutellarein-6,4'-dimethyl ether
Pectolinarigenin
Pectolinaringenin
5,7-Dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
5,7-dihydroxy-4',6-dimethoxyflavone

Biological Activity

[Description]:

Pectolinarigenin, isolated from Cirsium chanroenicum, is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity[1]. Pectolinarigenin has potent inhibitory activities on melanogenesis[2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

COX-2

5-LOX

[References]

[1]. Lim H, et al. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol Pharm Bull. 2008 Nov;31(11):2063-7.

[2]. Lee S, et al. Pectolinarigenin, an aglycone of pectolinarin, has more potent inhibitory activities on melanogenesis than pectolinarin.Biochem Biophys Res Commun. 2017 Nov 4;493(1):765-772.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
565.5±50.0 °C at 760 mmHg

[ Melting Point ]:
220-223°

[ Molecular Formula ]:
C₁₇H₁₄O₆

[ Molecular Weight ]:
314.289

[ Flash Point ]:
212.3±23.6 °C

[ Exact Mass ]:
314.079041

[ PSA ]:
89.13000

[ LogP ]:
2.64

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.646

[ Storage condition ]:
2-8C

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%